Computational Analysis of Alternative Splicing and Transcriptional Initiation Patterns
ثبت نشده
چکیده
منابع مشابه
An Algorithm for Classification of Alternative Splicing and Transcriptional Initiation and Its Genome-Wide Application
We developed an algorithm that classifies all observed units of alternative splicing and transcriptional initiation and termination (UASTs) into an extendable set of distinct elementary patterns, when a collection of alignments between genomic DNA sequences and a set of cDNA/EST sequences are provided. The algorithm first converts aligned exon-intron structures into bit arrays, extracts UASTs, ...
متن کاملColony Forming Unit Endothelial Cells Do not Exhibit Telomerase Alternative Splicing Variants and Activity
Introduction: Endothelial progenitor colony forming unit-endothelial cells (CFU-EC) were first believed to be the progenitors of endothelial cells, named endothelial progenitor cells. Further studies revealed that they are monocytes regulating vasculogenesis. The main hindrance of these cells for therapeutic purposes is their low frequency and limited replicative potentials. This study was unde...
متن کاملAutomated classification of alternative splicing and transcriptional initiation and construction of visual database of classified patterns
MOTIVATION Large-scale detection and classification of alternative splicing and transcriptional initiation (ASTI) is the first step towards detailed studies of the functional implication and mechanisms of these phenomena. RESULTS We have developed an algorithm that classifies all observed units of ASTI into an extendable set of distinct types (e.g. cassette type) by converting a collection of...
متن کاملHistone Modifications Are Associated with Transcript Isoform Diversity in Normal and Cancer Cells
Mechanisms that generate transcript diversity are of fundamental importance in eukaryotes. Although a large fraction of human protein-coding genes and lincRNAs produce more than one mRNA isoform each, the regulation of this phenomenon is still incompletely understood. Much progress has been made in deciphering the role of sequence-specific features as well as DNA-and RNA-binding proteins in alt...
متن کاملDifferential expression of alternatively spliced mRNAs of Arabidopsis SR protein homologs, atSR30 and atSR45a, in response to environmental stress.
Serine/arginine-rich (SR) proteins are associated with either the regulation or the execution of both constitutive splicing and the selection of alternative splice sites in animals and plants. We demonstrated the molecular characterization of a homolog of SR protein, atSR45a, in Arabidopsis plants. Six types of mRNA variants (atSR45a-1a-e and atSR45a-2) were generated by the alternative selecti...
متن کامل